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Studies (75, 76) have shown that NOR can inhibit the destruction of bone and cartilage in AIA rats by reducing the expression of RANKL, IL-6, PGE2 and MMP-13 through the p38/ERK/AKT/AP-1 pathway

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Generally, most healthcare providers do not recommend taking these medications together because this combination has not been well studied in clinical trials and is not FDA-approved for safety and efficacy